3017- Basic and clinical immunology – 3017: A functional polymorphism in IL-5 receptor alpha may influence asthma severity in patients with aspirin-exacerbated respiratory disease
نویسندگان
چکیده
Background Eosinophilic infiltration into the tissues of the airway is a central feature of aspirin-exacerbated respiratory disease (AERD). Eosinophil activation and survival are profoundly influenced by IL-5 and its receptor, IL-5R. In patients susceptible to allergic disorders, IL5RA polymorphisms have been reported, however, an association with AERD remains unclear. We hypothesise that the presence of IL5RA polymorphisms will increase the genetic susceptibility to AERD.
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2013